• EDUCATIONAL PROFILE

    • Ph.D (2022); Chemistry CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, Kerala, India.
    • Thesis: Transition Metal-Free Transformations of α,β-Unsaturated Ketones to Heterocycles of Medicinal Relevance.
    • M.Sc. (2014) Chemistry St. Joseph’s College, Devagiri, University of Calicut, Kerala.
    • B.Sc. (2012); Chemistry St. Joseph’s College, Devagiri, University of Calicut, Kerala

    CAREER DETAILS

    • April 2025 – Till Date: Scientist B, CWRDM, Kozhikode, Kerala, India.
    • September 2023 - 2024: Assistant Professor on contract basis, Department of Chemistry, University of Kerala, Thiruvananthapuram, Kerala, India.

    AWARDS

    • Best poster award at the CSIR- Inter-Institutional Students Conference (SU-CHEM Yuva,) held at CSIR-IICT, Hyderabad, India, 24-26 July 2019.
    • Senior Research Fellowship (SRF) University Grants Commission, India, 2016 August.
    • Junior Research Fellowship (JRF) and National Eligibility Test (NET) for College Lecturer with All India Rank 64, University Grants Commission, India, 2014 December

Synthesis and biological evaluation of small-molecule-based anti-biofilm agents to manage biofilm formation in potable water (SEED grant project)

Synthesis and biological evaluation of small-molecule-based anti-biofilm agents to manage biofilm formation in potable water (SEED grant project)

Principal Investigator:
Dr. Ashitha K T
Funding Agency:
SEED GRANT, KSCSTE
Duration:
1 Year
Budget:
Rs. 5 Lakhs
Details

Ashitha, K. T.; Lakshmi, S.; Anjali, S.; Ajay Krishna; Ved Prakash; Anbumani, S.; Priya, S.; Sasidhar, B. S. Design and discovery of carboxamide-based pyrazole conjugates with multifaceted potential against Triple-Negative Breast cancer MDA-MB-231 cells. Bioorg. Med. Chem. Lette., 2024, 113 129960, https://doi.org/10.1016/j.bmcl.2024.129960.

Ashitha, K. T.; Krishna, A.; Basavaraja, D.; Sasidhar, B. S. Recent advances in the transition metal-free synthesis of heterocycles from α, β-unsaturated ketones. Org. Chem. Front., 2022, 9, 5306-5357. https://doi.org/10.1039/D2QO00278G.

Ashitha, K. T.; Vinaya, P. P.; Krishna, A.; Vincent, D. C.; Jalaja, R.; Varughese, S.; Somappa, S. B. I2/TBHP mediated diastereoselective synthesis of spiroaziridines. Org. Biomol. Chem. 2020, 18, 1588–1593. https://doi.org/10.1039/C9OB02711D.

Ashitha, K. T.; Praveen Kumar, V.; Fathimath Salfeena, C. T.; Sasidhar, B. S. BF3·OEt2 mediated tandem annulation: A strategy to construct functionalized chromeno- and pyrano-fused pyridines. J. Org. Chem. 2018, 83, 113–124. https://doi.org/10.1021/acs.joc.7b02463.
As Co-author
Details

Ajay Krishna M. S.; Ashitha, K. T.; Prabhakara Bhat. M.; Rudrappa, M.; Sandhya, K. S.; Lima, N. C.; Basavaraja, D.; Varughese, S.; Nayaka, S.; Somappa, S. B. Dual-acting β-Aminothiochoromones; Design, synthesis, and evaluation as antimicrobial and anti-angiogenic agents. Bioorg. Med. Chem. Lett. 2025, 130140. https://doi.org/10.1016/j.bmcl.2025.130140

Basavaraja, D.; Athira, C. S.; Siddalingeshwar V. D.; Ashitha, K. T. Multicomponent synthesis of spiro-dihydropyridine oxindoles via cascade spirocyclization of Knoevenagel/aza-Michael adducts. J. Org. Chem. 2022, 87, 13556–13563. https://doi.org/10.1021/acs.joc.2c01063.

Ajay Krishna, M. S.; Mohan, S.; Ashitha, K. T.; Chandramouli, M.; Kumaran, A.; Ningaiah, S.; Babu, S.; Sasidhar, B. S. Marine based natural products: Exploring the recent developments in the identification of antimicrobial agents. Chem. Biodiversity 2022, 19, e202200513. https://doi.org/10.1002/cbdv.202200513.

Fathimath Salfeena, C. T.; Basavaraja; Ashitha, K. T.; Kumar, V. P.; Varughese, S.; Suresh, C. H.; Sasidhar, B. S. Synthesis of symmetrical and unsymmetrical triarylpyrylium ions: via an inverse electron demand Diels-Alder reaction. Chem. Commun. 2018, 54, 12463–12466. https://doi.org/10.1039/C8CC06444J.

Mohan, B.; Salfeena, C. T. F.; Ashitha, K. T.; Krishnan, G. V.; Jesmina, A. R. S.; Varghese, A. M.; Patil, S. A.; Kumar, B. N. S. D.; Sasidhar, B. S. Functionalized pyrimidines from alkynes and nitriles: Application towards the synthesis of marine natural product meridianin analogs. ChemistrySelect 2018, 3, 6394–6398. https://doi.org/10.1002/slct.201801126.

Jalaja, R.; Leela, S. G.; Valmiki, P. K.; Salfeena, C. T. F.; Ashitha, K. T.; Krishna Rao, V. R. D.; Nair, M. S.; Gopalan, R. K.; Somappa, S. B. Discovery of natural product derived labdane appended triazoles as potent pancreatic lipase inhibitors. ACS Med. Chem. Lett. 2018, 9, 662–666. https://doi.org/10.1021/acsmedchemlett.8b00109.

Fathimath Salfeena, C. T.; Ashitha, K. T.; Sasidhar, B. S. BF3·Et2O Mediated one-step synthesis N-substituted-1,2-dihydropyridines, indenopyridines and 5,6-dihydroisoquinolines. Org. Biomol. Chem. 2016, 14, 10165–10169. https://doi.org/10.1039/C6OB02133F.
BF3·OEt2-Mediated tandem annulation: A strategy to construct functionalized chromeno and pyrano fused pyridines. Poster presentation at XIV J-NOST Conference for Research Scholars held at CSIR-IICT, Hyderabad, India, 28 November – 1 December 2018.

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